BAIT
SWI6
SPAC824.10c, SPAC664.01c
HP1 family chromodomain protein Swi6
GO Process (12)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- cellular protein localization [IMP]
- chromatin remodeling [NAS]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- chromosome passenger complex localization to kinetochore [NAS]
- donor selection [IMP]
- gene conversion at mating-type locus [IMP]
- mating type switching [IMP]
- mitotic sister chromatid cohesion [IGI]
- negative regulation of reciprocal meiotic recombination [IMP]
- protein localization to chromosome, centromeric region [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
PSM1
smc1, SPBC29A10.04
mitotic cohesin complex subunit Psm1
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A screen for cohesion mutants uncovers Ssl3, the fission yeast counterpart of the cohesin loading factor Scc4.
Sister-chromatid cohesion is mediated by cohesin, a ring-shape complex made of four core subunits called Scc1, Scc3, Smc1, and Smc3 in Saccharomyces cerevisiae (Rad21, Psc3, Psm1, and Psm3 in Schizosaccharomyces pombe). How cohesin ensures cohesion is unknown, although its ring shape suggests that it may tether sister DNA strands by encircling them . Cohesion establishment is a two-step process. Cohesin ... [more]
Curr. Biol. May. 09, 2006; 16(9);875-81 [Pubmed: 16682348]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID