PDGFRB
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway [TAS]
- aorta morphogenesis [ISS]
- cardiac myofibril assembly [ISS]
- cell chemotaxis [IDA]
- cell migration [IMP]
- cell migration involved in coronary angiogenesis [ISS]
- cell migration involved in vasculogenesis [ISS]
- cellular response to platelet-derived growth factor stimulus [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- metanephric glomerular capillary formation [ISS]
- metanephric glomerular mesangial cell proliferation involved in metanephros development [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol metabolic process [IMP]
- phosphatidylinositol-mediated signaling [IMP, TAS]
- platelet-derived growth factor receptor signaling pathway [IDA]
- platelet-derived growth factor receptor-beta signaling pathway [IMP]
- positive regulation of DNA biosynthetic process [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISS]
- positive regulation of MAP kinase activity [ISS]
- positive regulation of calcium ion import [ISS]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of chemotaxis [ISS]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [ISS]
- positive regulation of mitosis [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of reactive oxygen species metabolic process [ISS]
- positive regulation of smooth muscle cell migration [IMP, ISS]
- positive regulation of smooth muscle cell proliferation [IMP, ISS]
- protein autophosphorylation [IDA]
- regulation of actin cytoskeleton organization [ISS]
- retina vasculature development in camera-type eye [ISS]
- signal transduction [IDA]
- smooth muscle cell chemotaxis [ISS]
Gene Ontology Molecular Function- platelet activating factor receptor activity [TAS]
- platelet-derived growth factor beta-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- platelet-derived growth factor-activated receptor activity [TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor binding [IPI]
- vascular endothelial growth factor binding [IPI]
- platelet activating factor receptor activity [TAS]
- platelet-derived growth factor beta-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- platelet-derived growth factor-activated receptor activity [TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor binding [IPI]
- vascular endothelial growth factor binding [IPI]
Gene Ontology Cellular Component
HIP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.
Huntingtin-interacting protein 1 (HIP1) binds inositol lipids, clathrin, actin, and receptor tyrosine kinases (RTKs). HIP1 is elevated in many tumors, and its expression is prognostic in prostate cancer. HIP1 overexpression increases levels of the RTK epidermal growth factor receptor (EGFR) and transforms fibroblasts. Here we report that HIP1 is tyrosine phosphorylated in the presence of EGFR and platelet-derived growth factor ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HIP1 PDGFRB | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID