A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Genetic and functional interaction between Ryh1 and Ypt3: two Rab GTPases that function in S. pombe secretory pathway.

He Y, Sugiura R, Ma Y, Kita A, Deng L, Takegawa K, Matsuoka K, Shuntoh H, Kuno T

We have previously isolated ypt3-i5 mutant and showed that Ypt3 GTPase functions in the fission yeast secretory pathway. Here, the same genetic screen led to the isolation of ryh1-i6, a mutant allele of the ryh1+ gene encoding a homolog of Rab6. The ryh1-i6 mutant showed phenotypes that support its role in retrograde traffic from endosome to the Golgi. Interestingly, ryh1+ ... [more]

Genes Cells Mar. 01, 2006; 11(3);207-21 [Pubmed: 16483310]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
YPT3 RYH1	Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Tatebe H (2010)	Low	-	BioGRID	478116

Curated By

BioGRID

Interaction Summary

YPT3

Gene Ontology Biological Process

Gene Ontology Molecular Function

GTPase activity [ISS]

Gene Ontology Cellular Component

RYH1