FBXO7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MYOG
Gene Ontology Biological Process
- cellular response to estradiol stimulus [ISS]
- mRNA transcription from RNA polymerase II promoter [TAS]
- muscle cell differentiation [TAS]
- muscle cell fate commitment [ISS]
- negative regulation of cell proliferation [ISS]
- positive regulation of cell cycle arrest [ISS]
- positive regulation of muscle atrophy [ISS]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of myoblast differentiation [ISS]
- positive regulation of myotube differentiation [ISS]
- positive regulation of skeletal muscle fiber development [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- regulation of myoblast fusion [ISS]
- regulation of satellite cell proliferation [ISS]
- response to denervation involved in regulation of muscle adaptation [ISS]
- response to electrical stimulus involved in regulation of muscle adaptation [ISS]
- response to muscle activity involved in regulation of muscle adaptation [ISS]
- skeletal muscle tissue development [TAS]
- striated muscle atrophy [ISS]
Gene Ontology Molecular Function- E-box binding [ISS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISS]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, TAS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS]
- E-box binding [ISS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISS]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, TAS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS]
Gene Ontology Cellular Component
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.
Fbxo7 is a clinically relevant F-box protein, associated with both cancer and Parkinson's disease (PD). Additionally, SNPs within FBXO7 are correlated with alterations in red blood cell parameters. Point mutations within FBXO7 map within specific functional domains, including near its F-box domain and its substrate recruiting domains, suggesting that deficiencies in SCF(Fbxo7/PARK15) ubiquitin ligase activity are mechanistically linked to early-onset ... [more]
Throughput
- High Throughput
Additional Notes
- substrates identified by screening using the Invitrogen Protoarray v5.0
Curated By
- BioGRID