SPBC20F10.11, SPBC17D11.01
NEDD8 protease Nep1
GO Process (5)
GO Function (2)
GO Component (2)
Schizosaccharomyces pombe (972h)


mitotic spindle checkpoint protein Mad2
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Nep1, a Schizosaccharomyces pombe deneddylating enzyme.

Zhou L, Watts FZ

Nedd8 is a ubiquitin-like modifier that is attached to the cullin components of E3 ubiquitin ligases. More recently, p53 has also been shown to be Nedd8-modified. Nedd8 attachment occurs in a manner similar to that observed for other ubiquitin-like modifiers. In the present study, we report on the characterization of Nep1, a deneddylating enzyme in fission yeast (Schizosaccharomyces pombe). Unlike ... [more]

Biochem. J. Jul. 15, 2005; 389(0);307-14 [Pubmed: 15769255]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID