BAIT

FBXO7

FBX, FBX07, FBX7, PARK15, PKPS, LL22NC03-28H9.2
F-box protein 7
Autophagy Project
Parkinson's Disease Project
UPS Project
Homo sapiens
PREY

MARK2

EMK-1, EMK1, PAR-1, Par-1b, Par1b
MAP/microtubule affinity-regulating kinase 2
Alzheimer's Disease Project
Autism spectrum disorder (ASD) Project
UPS Project
Homo sapiens

Biochemical Activity (Ubiquitination)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.

Teixeira FR, Randle SJ, Patel SP, Mevissen TE, Zenkeviciute G, Koide T, Komander D, Laman H

Fbxo7 is a clinically relevant F-box protein, associated with both cancer and Parkinson's disease (PD). Additionally, SNPs within FBXO7 are correlated with alterations in red blood cell parameters. Point mutations within FBXO7 map within specific functional domains, including near its F-box domain and its substrate recruiting domains, suggesting that deficiencies in SCF(Fbxo7/PARK15) ubiquitin ligase activity are mechanistically linked to early-onset ... [more]

Biochem. J. Oct. 15, 2016; 473(20);3563-3580 [Pubmed: 27503909]

Throughput

  • High Throughput

Additional Notes

  • substrates identified by screening using the Invitrogen Protoarray v5.0

Curated By

  • BioGRID