FBXO7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FGF10
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- actin cytoskeleton reorganization [IDA]
- activation of MAPK activity [IDA]
- branching morphogenesis of an epithelial tube [IDA]
- bud outgrowth involved in lung branching [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- epithelial cell proliferation [IDA]
- fibroblast growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification [IDA]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- lacrimal gland development [IMP]
- lung epithelium development [IDA]
- lung saccule development [IMP]
- mesonephros development [IEP]
- metanephros development [IEP]
- negative regulation of cell cycle arrest [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive chemotaxis [IDA]
- positive regulation of ATPase activity [IDA]
- positive regulation of DNA repair [IDA]
- positive regulation of DNA replication [IMP]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Ras protein signal transduction [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of epithelial cell proliferation involved in wound healing [NAS]
- positive regulation of hair follicle cell proliferation [IDA]
- positive regulation of keratinocyte migration [IDA]
- positive regulation of keratinocyte proliferation [IDA]
- positive regulation of lymphocyte proliferation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of urothelial cell proliferation [IDA]
- protein localization to cell surface [IDA]
- radial glial cell differentiation [ISS]
- regulation of saliva secretion [IMP]
- salivary gland development [IMP]
- secretion by lung epithelial cell involved in lung growth [IDA]
- tear secretion [IMP]
- thymus development [IDA]
- urothelial cell proliferation [IDA]
- wound healing [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.
Fbxo7 is a clinically relevant F-box protein, associated with both cancer and Parkinson's disease (PD). Additionally, SNPs within FBXO7 are correlated with alterations in red blood cell parameters. Point mutations within FBXO7 map within specific functional domains, including near its F-box domain and its substrate recruiting domains, suggesting that deficiencies in SCF(Fbxo7/PARK15) ubiquitin ligase activity are mechanistically linked to early-onset ... [more]
Throughput
- High Throughput
Additional Notes
- substrates identified by screening using the Invitrogen Protoarray v5.0
Curated By
- BioGRID