PREY

KDM4C

GASC1, JHDM3C, JMJD2C, TDRD14C, bA146B14.1, RP11-169L18.1
lysine (K)-specific demethylase 4C
Homo sapiens

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

Wong AS, Choi GC, Cui CH, Pregernig G, Milani P, Adam M, Perli SD, Kazer SW, Gaillard A, Hermann M, Shalek AK, Fraenkel E, Lu TK

The orchestrated action of genes controls complex biological phenotypes, yet the systematic discovery of gene and drug combinations that modulate these phenotypes in human cells is labor intensive and challenging to scale. Here, we created a platform for the massively parallel screening of barcoded combinatorial gene perturbations in human cells and translated these hits into effective drug combinations. This technology ... [more]

Proc. Natl. Acad. Sci. U.S.A. Mar. 01, 2016; 113(9);2544-9 [Pubmed: 26864203]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: growth abnormality (HP:0001507) [ovcar-8/adr cell (BTO:0004189)]

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
BRD4 KDM4C
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-BioGRID
2463326

Curated By

  • BioGRID