BAIT
ESO1
SPBC16A3.11
sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein
GO Process (7)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- DNA biosynthetic process [ISO]
- DNA repair [ISO]
- establishment of mitotic sister chromatid cohesion [IMP]
- peptidyl-lysine N6-acetylation [IMP]
- positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric [IMP]
- regulation of maintenance of mitotic sister chromatid cohesion [TAS]
- translesion synthesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
MIS4
SPAC31A2.05c
adherin, cohesin loading factor Mis4
GO Process (7)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IMP]
- cellular response to nitrogen starvation [IMP]
- cohesin localization to chromatin [IMP]
- mitotic sister chromatid cohesion [IGI, IMP]
- mitotic spindle organization [IMP]
- negative regulation of G0 to G1 transition [IMP]
- positive regulation of maintenance of mitotic sister chromatid cohesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phase.
Sister chromatid cohesion is essential for cell viability. We have isolated a novel temperature-sensitive lethal mutant named eso1-H17 that displays spindle assembly checkpoint-dependent mitotic delay and abnormal chromosome segregation. At the permissive temperature, the eso1-H17 mutant shows mild sensitivity to UV irradiation and DNA-damaging chemicals. At the nonpermissive temperature, the mutant is arrested in M phase with a viability loss ... [more]
Mol. Cell. Biol. May. 01, 2000; 20(10);3459-69 [Pubmed: 10779336]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID