HIF1AN
Gene Ontology Biological Process
- cellular response to hypoxia [TAS]
- negative regulation of Notch signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- oxidation-reduction process [IDA]
- peptidyl-asparagine hydroxylation [IDA, IMP]
- peptidyl-aspartic acid hydroxylation [IDA]
- peptidyl-histidine hydroxylation [IDA]
- positive regulation of myoblast differentiation [IDA]
- positive regulation of vasculogenesis [NAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
Gene Ontology Molecular Function- NF-kappaB binding [IPI]
- Notch binding [IPI]
- ankyrin repeat binding [IPI]
- carboxylic acid binding [IDA]
- cofactor binding [IDA]
- iron ion binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [EXP]
- oxygen sensor activity [NAS]
- peptidyl-asparagine 3-dioxygenase activity [IDA, IMP]
- peptidyl-histidine dioxygenase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- zinc ion binding [IDA]
- NF-kappaB binding [IPI]
- Notch binding [IPI]
- ankyrin repeat binding [IPI]
- carboxylic acid binding [IDA]
- cofactor binding [IDA]
- iron ion binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [EXP]
- oxygen sensor activity [NAS]
- peptidyl-asparagine 3-dioxygenase activity [IDA, IMP]
- peptidyl-histidine dioxygenase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
ANK3
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [IMP]
- axonogenesis [ISS]
- cytoskeletal anchoring at plasma membrane [TAS]
- establishment of protein localization [IMP]
- maintenance of protein location in plasma membrane [IGI]
- membrane assembly [IMP]
- mitotic cytokinesis [IMP]
- neuronal action potential [ISS]
- plasma membrane organization [IMP]
- positive regulation of gene expression [ISS]
- positive regulation of membrane depolarization during cardiac muscle cell action potential [ISS]
- positive regulation of membrane potential [ISS]
- positive regulation of sodium ion transmembrane transporter activity [ISS]
- positive regulation of sodium ion transport [ISS]
- protein localization to plasma membrane [IGI, IMP]
- protein targeting to plasma membrane [IMP]
- regulation of potassium ion transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISS]
- axon initial segment [ISS]
- basal plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- cell surface [ISS]
- costamere [TAS]
- endoplasmic reticulum [TAS]
- intercalated disc [ISS]
- lateral plasma membrane [IDA]
- node of Ranvier [ISS]
- plasma membrane [ISS]
- sarcolemma [IDA]
- spectrin-associated cytoskeleton [ISS]
- tight junction [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways.
Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG) dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been described for these enzymes. Using quantitative interaction proteomics, we screened for substrates of the proline hydroxylase PHD3 and the ... [more]
Throughput
- High Throughput
Additional Notes
- Source of HIF1AN not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HIF1AN ANK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9999 | BioGRID | 2225666 | |
| HIF1AN ANK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3136050 |
Curated By
- BioGRID