A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phase.

Tanaka K, Yonekawa T, Kawasaki Y, Kai M, Furuya K, Iwasaki M, Murakami H, Yanagida M, Okayama H

Sister chromatid cohesion is essential for cell viability. We have isolated a novel temperature-sensitive lethal mutant named eso1-H17 that displays spindle assembly checkpoint-dependent mitotic delay and abnormal chromosome segregation. At the permissive temperature, the eso1-H17 mutant shows mild sensitivity to UV irradiation and DNA-damaging chemicals. At the nonpermissive temperature, the mutant is arrested in M phase with a viability loss ... [more]

Mol. Cell. Biol. May. 01, 2000; 20(10);3459-69 [Pubmed: 10779336]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ESO1 RAD21	Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.	Birot A (2017)	Low	-	BioGRID	2333602

Curated By

BioGRID

Interaction Summary

ESO1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA-directed DNA polymerase activity [ISO]acetyltransferase activity [ISS]peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IMP]protein binding [IPI]

Gene Ontology Cellular Component

RAD21