BAIT
ADRA2A
ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
adrenoceptor alpha 2A
GO Process (39)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS]
- Ras protein signal transduction [TAS]
- Rho protein signal transduction [TAS]
- actin cytoskeleton organization [TAS]
- activation of MAPK activity by adrenergic receptor signaling pathway [IDA]
- activation of protein kinase B activity [IDA]
- activation of protein kinase activity [IDA]
- adenylate cyclase-inhibiting adrenergic receptor signaling pathway [IDA]
- blood coagulation [TAS]
- cellular component movement [TAS]
- cellular response to hormone stimulus [IGI]
- energy reserve metabolic process [TAS]
- epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway [IDA]
- glucose homeostasis [IMP]
- intestinal absorption [TAS]
- negative regulation of adenylate cyclase activity [ISS]
- negative regulation of adrenergic receptor signaling pathway [ISS]
- negative regulation of cAMP biosynthetic process [IDA, ISS]
- negative regulation of calcium ion transmembrane transporter activity [ISS]
- negative regulation of calcium ion transport [ISS]
- negative regulation of calcium ion-dependent exocytosis [IC]
- negative regulation of epinephrine secretion [NAS]
- negative regulation of insulin secretion [IMP]
- negative regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- negative regulation of lipid catabolic process [IGI]
- negative regulation of norepinephrine secretion [NAS, TAS]
- phospholipase C-activating adrenergic receptor signaling pathway [IDA]
- platelet activation [TAS]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [TAS]
- positive regulation of cytokine production [IDA]
- positive regulation of epidermal growth factor-activated receptor activity [IDA]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of potassium ion transport [ISS]
- positive regulation of wound healing [IMP]
- regulation of insulin secretion [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- alpha-1B adrenergic receptor binding [ISS]
- alpha-2C adrenergic receptor binding [IPI]
- alpha2-adrenergic receptor activity [IDA, ISS]
- epinephrine binding [IDA]
- heterotrimeric G-protein binding [IDA]
- norepinephrine binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISS]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- thioesterase binding [IPI]
- alpha-1B adrenergic receptor binding [ISS]
- alpha-2C adrenergic receptor binding [IPI]
- alpha2-adrenergic receptor activity [IDA, ISS]
- epinephrine binding [IDA]
- heterotrimeric G-protein binding [IDA]
- norepinephrine binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISS]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- thioesterase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
GGA3
golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GO Process (1)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export.
Molecular mechanisms governing the anterograde trafficking of nascent G protein-coupled receptors (GPCRs) are poorly understood. Here, we have studied the regulation of cell surface transport of α2-adrenergic receptors (α2-ARs) by GGA3 (Golgi-localized, γ-adaptin ear domain homology, ADP ribosylation factor-binding protein 3), a multidomain clathrin adaptor protein that sorts cargo proteins at the trans-Golgi network (TGN) to the endosome/lysosome pathway. By ... [more]
Mol. Cell. Biol. Jan. 25, 2016; 36(7);1152-63 [Pubmed: 26811329]
Throughput
- Low Throughput
Curated By
- BioGRID