BAIT
EGLN3
HIFP4H3, HIFPH3, PHD3
egl-9 family hypoxia-inducible factor 3
GO Process (9)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IEP]
- apoptotic process [IEP]
- cellular response to hypoxia [TAS]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [IDA]
- protein hydroxylation [IDA]
- regulation of cell proliferation [IEP]
- regulation of neuron apoptotic process [ISS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IEP]
Gene Ontology Molecular Function
Homo sapiens
PREY
DOCK7
EIEE23, ZIR2, RP4-740B20.2
dedicator of cytokinesis 7
GO Process (8)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- activation of Rac GTPase activity [IDA]
- axonogenesis [IMP]
- establishment of neuroblast polarity [IMP]
- interkinetic nuclear migration [ISS]
- microtubule cytoskeleton organization [IMP]
- neuron projection development [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- regulation of neurogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways.
Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG) dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been described for these enzymes. Using quantitative interaction proteomics, we screened for substrates of the proline hydroxylase PHD3 and the ... [more]
Cell Rep Mar. 22, 2016; 14(11);2745-60 [Pubmed: 26972000]
Throughput
- High Throughput
Additional Notes
- Source of EGLN3 not clear
Curated By
- BioGRID