A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Repair of damaged and mismatched DNA by the XPC homologues Rhp41 and Rhp42 of fission yeast.

Marti TM, Kunz C, Fleck O

Rhp41 and Rhp42 of Schizosaccharomyces pombe are homologues of human XPC, which is involved in nucleotide excision repair (NER) of damaged DNA. Inactivation of rhp41 caused moderate sensitivity to ultraviolet (UV) radiation. In addition, an increase of mitotic mutation rates was observed in the rhp41 mutant, which was dependent on active translesion polymerase Z. UV sensitivity and mutation rates were ... [more]

Genetics Jun. 01, 2003; 164(2);457-67 [Pubmed: 12807767]

Throughput

Low Throughput

Ontology Terms

phenotype: uv resistance (APO:0000085)
phenotype: vegetative growth (APO:0000106)

Additional Notes

double mutants show increased sensitivity to UV

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
RHP41 RHP26	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Marti TM (2003)	Low	-	BioGRID	246421
RHP26 RHP41	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Kanamitsu K (2011)	Low	-	BioGRID	543799

Curated By

BioGRID

Interaction Summary

RHP41

Gene Ontology Biological Process

Gene Ontology Cellular Component

RHP26