BAIT
TRIM14
tripartite motif containing 14
GO Process (4)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Homo sapiens
PREY
DYNLL1
DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1
dynein, light chain, LC8-type 1
GO Process (11)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- actin cytoskeleton organization [TAS]
- anatomical structure morphogenesis [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- apoptotic process [TAS]
- female gamete generation [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic cell cycle [TAS]
- negative regulation of phosphorylation [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.
Mitochondrial antiviral signaling platform protein (MAVS) acts as a central hub for RIG-I receptor proximal signal propagation. However, key components in the assembly of the MAVS mitochondrial platform that promote RIG-I mitochondrial localization and optimal activation are still largely undefined. Employing pooled RNAi and yeast two-hybrid screenings, we report that the mitochondrial adaptor protein tripartite motif (TRIM)14 provides a docking ... [more]
Mol. Cell Oct. 19, 2017; 68(2);293-307.e5 [Pubmed: 29053956]
Throughput
- High Throughput
Additional Notes
- evidence from proximity label-MS experiment, specifically APEX-2 biotin labeling
Curated By
- BioGRID