INT6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAS1
Gene Ontology Biological Process
- Cdc42 protein signal transduction [IC]
- conjugation with cellular fusion [IMP]
- establishment or maintenance of cell polarity regulating cell shape [TAS]
- fungal-type cell wall biogenesis [IMP]
- induction of conjugation with cellular fusion [IMP]
- meiotic cell cycle [IMP]
- mitotic cell cycle arrest in response to pheromone [TAS]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- positive regulation of protein localization to nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter by pheromones [IMP]
- protein localization to plasma membrane [IMP]
- regulation of conjugation with cellular fusion [IMP]
- signal transduction involved in conjugation with cellular fusion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation.
The INT6 gene has been implicated in human breast cancer formation, but its function is unknown. We isolated an Int6 homolog from fission yeast, Yin6, by its binding to a conserved protein in the Ras pathway, Moe1. Yin6 and Moe1 converge on the same protein complex to promote microtubule instability/disassembly. Yin6 and Moe1 interact cooperatively: when either protein is absent, ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
- phenotype: cold sensitivity (APO:0000148)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| INT6 RAS1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 246469 | |
| INT6 RAS1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | PomBase | - | |
| RAS1 INT6 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 246465 | |
| RAS1 INT6 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 246467 | |
| INT6 RAS1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 246468 |
Curated By
- BioGRID