BAIT
ARMC8
GID5, HSPC056, VID28, S863-2
armadillo repeat containing 8
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
PRPS1
ARTS, CMTX5, DFN2, DFNX1, PPRibP, PRS-I, PRSI, RP11-540N4.1
phosphoribosyl pyrophosphate synthetase 1
GO Process (9)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- 5-phosphoribose 1-diphosphate biosynthetic process [TAS]
- carbohydrate metabolic process [TAS]
- hypoxanthine biosynthetic process [IMP]
- nervous system development [IMP]
- purine nucleobase metabolic process [IMP]
- purine nucleotide biosynthetic process [IMP]
- pyrimidine nucleotide biosynthetic process [NAS]
- small molecule metabolic process [TAS]
- urate biosynthetic process [IMP]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.
In yeast, the glucose-induced degradation-deficient (GID) E3 ligase selectively degrades superfluous gluconeogenic enzymes. Here, we identified all subunits of the mammalian GID/CTLH complex and provide a comprehensive map of its hierarchical organization and step-wise assembly. Biochemical reconstitution demonstrates that the mammalian complex possesses inherent E3 ubiquitin ligase activity, using Ube2H as its cognate E2. Deletions of multiple GID subunits compromise ... [more]
Elife Jun. 18, 2018; 7(); [Pubmed: 29911972]
Throughput
- High Throughput
Curated By
- BioGRID