INT6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAS1
Gene Ontology Biological Process
- Cdc42 protein signal transduction [IC]
- conjugation with cellular fusion [IMP]
- establishment or maintenance of cell polarity regulating cell shape [TAS]
- fungal-type cell wall biogenesis [IMP]
- induction of conjugation with cellular fusion [IMP]
- meiotic cell cycle [IMP]
- mitotic cell cycle arrest in response to pheromone [TAS]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- positive regulation of protein localization to nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter by pheromones [IMP]
- protein localization to plasma membrane [IMP]
- regulation of conjugation with cellular fusion [IMP]
- signal transduction involved in conjugation with cellular fusion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome.
Yin6 is a yeast homolog of Int6, which is implicated in tumorigenesis. We show that Yin6 binds to and regulates proteasome activity. Overexpression of Yin6 strengthens proteasome function while inactivation weakens and causes the accumulation of polyubiquitinated proteins including securin/Cut2 and cyclin/Cdc13. Yin6 regulates the proteasome by preferentially interacting with Rpn5, a conserved proteasome subunit, and affecting its localization/assembly. We ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| INT6 RAS1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 246469 | |
| INT6 RAS1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | PomBase | - | |
| RAS1 INT6 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 246465 | |
| INT6 RAS1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 246466 | |
| RAS1 INT6 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 246467 |
Curated By
- BioGRID