ZNF451
Gene Ontology Molecular Function
PML
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [ISS]
- PML body organization [IDA, IMP]
- apoptotic process [IDA]
- cell cycle arrest [IDA]
- cellular senescence [IDA]
- circadian regulation of gene expression [ISS]
- cytokine-mediated signaling pathway [TAS]
- endoplasmic reticulum calcium ion homeostasis [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- innate immune response [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISS]
- maintenance of protein location in nucleus [IDA]
- negative regulation of angiogenesis [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IMP]
- negative regulation of mitotic cell cycle [IDA]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of telomerase activity [IMP]
- negative regulation of telomere maintenance via telomerase [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of translation in response to oxidative stress [IDA]
- negative regulation of viral release from host cell [IDA]
- positive regulation of apoptotic process involved in mammary gland involution [IDA]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of histone deacetylation [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein complex assembly [IDA]
- protein stabilization [IDA]
- protein targeting [IDA, IMP]
- regulation of calcium ion transport into cytosol [ISS]
- regulation of circadian rhythm [ISS]
- regulation of double-strand break repair [IMP]
- regulation of protein phosphorylation [ISS]
- regulation of transcription, DNA-templated [IMP]
- response to cytokine [IDA]
- response to hypoxia [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Sumoylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability.
The small ubiquitin related modifier SUMO regulates protein functions to maintain cell homeostasis. SUMO attachment is executed by the hierarchical action of E1, E2 and E3 enzymes of which E3 ligases ensure substrate specificity. We recently identified the ZNF451 family as novel class of SUMO2/3 specific E3 ligases and characterized their function in SUMO chain formation. The founding member, ZNF451isoform1 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PML ZNF451 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3644054 |
Curated By
- BioGRID