BAIT
EGLN3
HIFP4H3, HIFPH3, PHD3
egl-9 family hypoxia-inducible factor 3
GO Process (9)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IEP]
- apoptotic process [IEP]
- cellular response to hypoxia [TAS]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [IDA]
- protein hydroxylation [IDA]
- regulation of cell proliferation [IEP]
- regulation of neuron apoptotic process [ISS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IEP]
Gene Ontology Molecular Function
Homo sapiens
PREY
MYO6
DFNA22, DFNB37, RP3-472A9.1
myosin VI
GO Process (9)
GO Function (7)
GO Component (19)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [IDA]
- actin filament-based movement [ISS, NAS]
- endocytosis [IMP, ISS]
- intracellular protein transport [ISS]
- membrane organization [TAS]
- metabolic process [ISS, NAS]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of secretion [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- DNA-directed RNA polymerase II, holoenzyme [IDA]
- Golgi apparatus [IDA]
- cell cortex [ISS]
- clathrin-coated endocytic vesicle [IDA]
- cytoplasm [IDA, ISS]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytosol [TAS]
- endocytic vesicle [ISS]
- extracellular vesicular exosome [IDA]
- filamentous actin [IDA, ISS]
- lysosomal membrane [TAS]
- membrane [IDA]
- nuclear membrane [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA, ISS]
- plasma membrane [TAS]
- ruffle [IDA]
- unconventional myosin complex [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways.
Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG) dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been described for these enzymes. Using quantitative interaction proteomics, we screened for substrates of the proline hydroxylase PHD3 and the ... [more]
Cell Rep Mar. 22, 2016; 14(11);2745-60 [Pubmed: 26972000]
Throughput
- High Throughput
Additional Notes
- Source of EGLN3 not clear
Curated By
- BioGRID