BAIT
EGLN3
HIFP4H3, HIFPH3, PHD3
egl-9 family hypoxia-inducible factor 3
GO Process (9)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IEP]
- apoptotic process [IEP]
- cellular response to hypoxia [TAS]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [IDA]
- protein hydroxylation [IDA]
- regulation of cell proliferation [IEP]
- regulation of neuron apoptotic process [ISS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IEP]
Gene Ontology Molecular Function
Homo sapiens
PREY
CDK5
PSSALRE
cyclin-dependent kinase 5
GO Process (25)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- axon extension [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell proliferation [TAS]
- negative regulation of neuron death [IDA]
- negative regulation of proteolysis [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- neuron apoptotic process [TAS]
- neuron differentiation [ISS, TAS]
- neuron migration [TAS]
- neuron projection development [ISS]
- oligodendrocyte differentiation [IDA]
- peptidyl-serine phosphorylation [IDA]
- phosphorylation [IDA]
- positive regulation of actin cytoskeleton reorganization [TAS]
- positive regulation of neuron apoptotic process [ISS]
- regulation of apoptotic process [TAS]
- regulation of cell cycle arrest [TAS]
- regulation of dendritic spine morphogenesis [ISS]
- regulation of synaptic plasticity [ISS, TAS]
- regulation of synaptic vesicle recycling [NAS]
- synapse assembly [TAS]
- synaptic transmission [TAS]
- synaptic vesicle endocytosis [TAS]
- synaptic vesicle exocytosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways.
Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG) dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been described for these enzymes. Using quantitative interaction proteomics, we screened for substrates of the proline hydroxylase PHD3 and the ... [more]
Cell Rep Mar. 22, 2016; 14(11);2745-60 [Pubmed: 26972000]
Throughput
- High Throughput
Additional Notes
- Source of EGLN3 not clear
Curated By
- BioGRID