MOE1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAS1
Gene Ontology Biological Process
- Cdc42 protein signal transduction [IC]
- conjugation with cellular fusion [IMP]
- establishment or maintenance of cell polarity regulating cell shape [TAS]
- fungal-type cell wall biogenesis [IMP]
- induction of conjugation with cellular fusion [IMP]
- meiotic cell cycle [IMP]
- mitotic cell cycle arrest in response to pheromone [TAS]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- positive regulation of protein localization to nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter by pheromones [IMP]
- protein localization to plasma membrane [IMP]
- regulation of conjugation with cellular fusion [IMP]
- signal transduction involved in conjugation with cellular fusion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors.
How a given Ras prreotein coordinates multiple signaling inputs and outputs is a fundamental issue of signaling specificity. Schizosaccharomyces pombe contains one Ras, Ras1, that has two distinct outputs. Ras1 activates Scd1, a presumptive guanine nucleotide exchange factor (GEF) for Cdc42, to control morphogenesis and chromosome segregation, and Byr2, a component of a mitogen-activated protein kinase cascade, to control mating. ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MOE1 RAS1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 247314 |
Curated By
- BioGRID