BAIT
TEA1
alp8, SPCC1223.06
cell end marker Tea1
GO Process (4)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
RAS1
ste5, SPAC17H9.09c
GTPase Ras1
GO Process (15)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- Cdc42 protein signal transduction [IC]
- conjugation with cellular fusion [IMP]
- establishment or maintenance of cell polarity regulating cell shape [TAS]
- fungal-type cell wall biogenesis [IMP]
- induction of conjugation with cellular fusion [IMP]
- meiotic cell cycle [IMP]
- mitotic cell cycle arrest in response to pheromone [TAS]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- positive regulation of protein localization to nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter by pheromones [IMP]
- protein localization to plasma membrane [IMP]
- regulation of conjugation with cellular fusion [IMP]
- signal transduction involved in conjugation with cellular fusion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors.
How a given Ras prreotein coordinates multiple signaling inputs and outputs is a fundamental issue of signaling specificity. Schizosaccharomyces pombe contains one Ras, Ras1, that has two distinct outputs. Ras1 activates Scd1, a presumptive guanine nucleotide exchange factor (GEF) for Cdc42, to control morphogenesis and chromosome segregation, and Byr2, a component of a mitogen-activated protein kinase cascade, to control mating. ... [more]
Mol. Cell. Biol. Jul. 01, 2002; 22(13);4598-606 [Pubmed: 12052869]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID