BAIT
EGLN3
HIFP4H3, HIFPH3, PHD3
egl-9 family hypoxia-inducible factor 3
GO Process (9)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IEP]
- apoptotic process [IEP]
- cellular response to hypoxia [TAS]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [IDA]
- protein hydroxylation [IDA]
- regulation of cell proliferation [IEP]
- regulation of neuron apoptotic process [ISS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IEP]
Gene Ontology Molecular Function
Homo sapiens
PREY
RAB3GAP1
P130, RAB3GAP, RAB3GAP130, WARBM1
RAB3 GTPase activating protein subunit 1 (catalytic)
GO Process (14)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- brain development [IMP]
- camera-type eye development [IMP]
- establishment of protein localization to endoplasmic reticulum membrane [IMP]
- face morphogenesis [IMP]
- hypothalamus development [IMP]
- lipid particle organization [IMP]
- positive regulation of GTP catabolic process [IMP]
- positive regulation of Rab GTPase activity [IMP, ISS]
- positive regulation of endoplasmic reticulum tubular network organization [IMP]
- positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [ISS]
- regulation of GTPase activity [IDA]
- regulation of calcium ion-dependent exocytosis of neurotransmitter [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of short-term neuronal synaptic plasticity [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways.
Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG) dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been described for these enzymes. Using quantitative interaction proteomics, we screened for substrates of the proline hydroxylase PHD3 and the ... [more]
Cell Rep Mar. 22, 2016; 14(11);2745-60 [Pubmed: 26972000]
Throughput
- High Throughput
Additional Notes
- Source of EGLN3 not clear
Curated By
- BioGRID