BAIT
SCD1
ral1, SPAC16E8.09
RhoGEF Scd1
GO Process (10)
GO Function (2)
GO Component (11)
Gene Ontology Biological Process
- Cdc42 protein signal transduction [IC]
- conjugation with cellular fusion [IMP]
- positive regulation of Rho GTPase activity [TAS]
- regulation of Cdc42 GTPase activity [TAS]
- regulation of barrier septum assembly [IGI]
- regulation of cell shape [IMP]
- regulation of endocytosis [IMP]
- regulation of establishment or maintenance of cell polarity regulating cell shape [IMP]
- regulation of spindle elongation [IMP]
- signal transduction involved in conjugation with cellular fusion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
GEF1
SPAC24H6.09
Cdc42 RhoGEF Gef1
GO Process (7)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- Cdc42 protein signal transduction [NAS]
- positive regulation of GTPase activity [EXP]
- positive regulation of Rho GTPase activity [IDA]
- positive regulation of establishment of cell polarity regulating cell shape [EXP]
- regulation of Rho GTPase activity [IDA]
- regulation of barrier septum assembly [IMP]
- regulation of establishment or maintenance of bipolar cell polarity regulating cell shape [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Gef1p and Scd1p, the Two GDP-GTP exchange factors for Cdc42p, form a ring structure that shrinks during cytokinesis in Schizosaccharomyces pombe.
Fission yeast Cdc42p, a small GTPase of the Rho family, is essential for cell proliferation and maintenance of the rod-like cell morphology. Scd1/Ral1p is a GDP-GTP exchange factor (GEF) for Cdc42p. This study and a parallel study by others establish that Gef1p is another GEF for Cdc42p. Deletions of gef1 and scd1 are synthetically lethal, generating round dead cells, and ... [more]
Mol. Biol. Cell Sep. 01, 2003; 14(9);3617-27 [Pubmed: 12972551]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID