BAIT

TSSC1

tumor suppressing subtransferable candidate 1
GO Process (0)
GO Function (0)
GO Component (0)
Rattus norvegicus
PREY

VPS52

Are1, Sacm2l
vacuolar protein sorting 52 homolog (S. cerevisiae)
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Rattus norvegicus

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

TSSC1 is novel component of the endosomal retrieval machinery.

Gershlick DC, Schindler C, Chen Y, Bonifacino JS

Endosomes function as a hub for multiple protein-sorting events, including retrograde transport to the trans-Golgi network (TGN) and recycling to the plasma membrane. These processes are mediated by tubular-vesicular carriers that bud from early endosomes and fuse with a corresponding acceptor compartment. Two tethering complexes named GARP (composed of ANG2, VPS52, VPS53, and VPS54 subunits) and EARP (composed of ANG2, ... [more]

Mol. Biol. Cell Dec. 15, 2015; 27(18);2867-78 [Pubmed: 27440922]

Throughput

  • Low Throughput

Curated By

  • BioGRID