A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Deletion of Mia1/Alp7 activates Mad2-dependent spindle assembly checkpoint in fission yeast.

Sato M, Koonrugsa N, Toda T, Vardy L, Tournier S, Millar JB

... [more]

Nat. Cell Biol. Sep. 01, 2003; 5(9);764-6; author reply 766 [Pubmed: 12951601]

Throughput

Low Throughput

Ontology Terms

phenotype: cytokinesis (APO:0000071)
phenotype: mitotic cell cycle (APO:0000072)

Additional Notes

simultaneous disruptions of mad2 and alp7 result in defective mitosis with uncontrolled cytokinesis

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ALP7 MAD2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Tang NH (2015)	Low	-	BioGRID	2334539
ALP7 MAD2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Sato M (2003)	Low	-	BioGRID	246664
ALP7 MAD2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Tang NH (2014)	Low	-	BioGRID	1022632

Curated By

BioGRID

Interaction Summary

ALP7

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

MAD2