BAIT
TMPO
CMD1T, LAP2, LEMD4, PRO0868, TP
thymopoietin
GO Process (0)
GO Function (2)
GO Component (5)
Gene Ontology Molecular Function
Homo sapiens
PREY
CLU
APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, AAG4
clusterin
GO Process (35)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell morphogenesis [IDA]
- central nervous system myelin maintenance [IMP]
- chaperone-mediated protein complex assembly [IDA]
- chaperone-mediated protein folding [IDA]
- complement activation [TAS]
- intrinsic apoptotic signaling pathway [IDA]
- lipid metabolic process [NAS]
- microglial cell activation [IDA]
- microglial cell proliferation [IDA]
- negative regulation of beta-amyloid formation [IDA]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of protein homooligomerization [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of beta-amyloid formation [ISS]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of neurofibrillary tangle assembly [IMP]
- positive regulation of neuron death [IDA, IMP]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of tau-protein kinase activity [IMP]
- positive regulation of tumor necrosis factor production [IDA]
- protein import [IDA]
- protein stabilization [IDA]
- regulation of beta-amyloid clearance [IDA]
- regulation of neuron death [IDA, IMP]
- regulation of neuronal signal transduction [IMP]
- release of cytochrome c from mitochondria [IC]
- response to misfolded protein [IDA]
- response to virus [IEP]
- reverse cholesterol transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical dendrite [IDA]
- blood microparticle [IDA]
- cytoplasm [IDA]
- extracellular matrix [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- mitochondrion [IDA]
- neurofibrillary tangle [IDA]
- perinuclear region of cytoplasm [IDA]
- platelet alpha granule lumen [TAS]
- spherical high-density lipoprotein particle [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) is becoming the major chronic liver disease in many countries. Its pathogenesis is multifactorial, but twin and familial studies indicate significant heritability, which is not fully explained by currently known genetic susceptibility loci. Notably, mutations in genes encoding nuclear lamina proteins, including lamins, cause lipodystrophy syndromes that include NAFLD. We hypothesized that variants in lamina-associated ... [more]
Hepatology May. 01, 2018; 67(5);1710-1725 [Pubmed: 28902428]
Throughput
- High Throughput
Curated By
- BioGRID