BAIT
BUB1
SPCC1322.12c
mitotic spindle checkpoint kinase Bub1
GO Process (7)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IMP]
- cellular protein localization [IMP]
- histone H2A-S121 phosphorylation [IDA]
- meiotic sister chromatid cohesion, centromeric [IGI]
- mitotic spindle assembly checkpoint [IMP]
- protein localization to kinetochore [IMP]
- signal transduction involved in mitotic spindle assembly checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
KLP6
SPBC649.01c, sot2, SPBC1685.15c
kinesin-like protein Klp6
GO Process (7)
GO Function (2)
GO Component (10)
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IDA]
- meiotic nuclear division [IMP]
- microtubule cytoskeleton organization involved in mitosis [IMP]
- mitotic actomyosin contractile ring assembly [IMP]
- mitotic sister chromatid segregation [IMP]
- regulation of microtubule depolymerization [IMP]
- regulation of microtubule polymerization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Kinesins klp5(+) and klp6(+) are required for normal chromosome movement in mitosis.
Proper mitotic chromosome segregation requires dynamic interactions between spindle microtubules and kinetochores. Here we demonstrate that two related fission yeast kinesins, klp5(+) and klp6(+), are required for normal chromosome segregation in mitosis. Null mutants frequently lack a normal metaphase chromosome alignment. Chromosome pairs move back and forth along the spindle for an extended period prior to sister chromatid separation, a ... [more]
J. Cell. Sci. Mar. 01, 2002; 115(0);931-40 [Pubmed: 11870212]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- text only
Curated By
- BioGRID