DIS1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KLP6
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IDA]
- meiotic nuclear division [IMP]
- microtubule cytoskeleton organization involved in mitosis [IMP]
- mitotic actomyosin contractile ring assembly [IMP]
- mitotic sister chromatid segregation [IMP]
- regulation of microtubule depolymerization [IMP]
- regulation of microtubule polymerization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Kinesins klp5(+) and klp6(+) are required for normal chromosome movement in mitosis.
Proper mitotic chromosome segregation requires dynamic interactions between spindle microtubules and kinetochores. Here we demonstrate that two related fission yeast kinesins, klp5(+) and klp6(+), are required for normal chromosome segregation in mitosis. Null mutants frequently lack a normal metaphase chromosome alignment. Chromosome pairs move back and forth along the spindle for an extended period prior to sister chromatid separation, a ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- text only
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KLP6 DIS1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 300485 |
Curated By
- BioGRID