A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilin.

Chang F, Drubin D, Nurse P

As in many other eukaryotic cells, cell division in fission yeast depends on the assembly of an actin ring that circumscribes the middle of the cell. Schizosaccharomyces pombe cdc12 is an essential gene necessary for actin ring assembly and septum formation. Here we show that cdc12p is a member of a family of proteins including Drosophila diaphanous, Saccharomyces cerevisiae BNI1, ... [more]

J. Cell Biol. Apr. 07, 1997; 137(1);169-82 [Pubmed: 9105045]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CDC12 CDC3	Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.	Chang F (1997)	Low	-	BioGRID	-
CDC3 CDC12	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Chang F (1997)	Low	-	BioGRID	-
CDC3 CDC12	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Yonetani A (2008)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

CDC12

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

CDC3