TRAF6
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [IMP]
- JNK cascade [ISO]
- T cell receptor signaling pathway [ISO]
- T-helper 1 type immune response [IMP]
- activation of NF-kappaB-inducing kinase activity [ISO]
- activation of protein kinase activity [ISO]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [IMP]
- bone remodeling [IMP]
- bone resorption [IMP]
- cell development [IMP]
- cellular response to lipopolysaccharide [ISO]
- cytokine-mediated signaling pathway [ISO]
- immune response [IMP]
- interleukin-1-mediated signaling pathway [IMP, ISO]
- myeloid dendritic cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [IMP]
- odontogenesis of dentin-containing tooth [IMP]
- organ morphogenesis [IMP]
- ossification [IMP]
- osteoclast differentiation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI, IMP, ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of T cell proliferation [IMP]
- positive regulation of interleukin-12 biosynthetic process [IMP]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of interleukin-6 biosynthetic process [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription regulatory region DNA binding [ISO]
- protein K63-linked ubiquitination [IDA, ISO]
- protein autoubiquitination [ISO, TAS]
- protein complex assembly [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IDA, IGI, IMP]
- regulation of immunoglobulin secretion [IDA]
- response to interleukin-1 [ISO]
- signal transduction [IDA, TAS]
Gene Ontology Molecular Function- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- signal transducer activity [TAS]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [IDA, IMP]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- signal transducer activity [TAS]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [IDA, IMP]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
Gene Ontology Cellular Component
RAC1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IGI]
- GTP catabolic process [IDA, ISO]
- Wnt signaling pathway, planar cell polarity pathway [IGI]
- actin cytoskeleton organization [ISO]
- actin filament organization [ISO]
- actin filament polymerization [IDA]
- anatomical structure arrangement [IMP]
- auditory receptor cell morphogenesis [IMP]
- axon guidance [IMP]
- bone resorption [ISO]
- cell adhesion [IDA]
- cell migration [IDA]
- cell motility [ISO]
- cell proliferation [ISO]
- cell-cell junction organization [IMP]
- cellular component movement [ISO]
- cerebral cortex radially oriented cell migration [IMP]
- chemotaxis [ISO]
- cochlea morphogenesis [IMP]
- cytoskeleton organization [IDA]
- dendrite development [IDA]
- dendrite morphogenesis [IGI]
- dopaminergic neuron differentiation [IGI]
- embryonic olfactory bulb interneuron precursor migration [IMP]
- endocytosis [IDA]
- engulfment of apoptotic cell [IDA]
- epithelial cell morphogenesis [IMP]
- hyperosmotic response [IDA]
- lamellipodium assembly [IDA, ISO, TAS]
- localization within membrane [ISO]
- mast cell chemotaxis [ISO]
- negative regulation of interleukin-23 production [ISO]
- phagocytosis, engulfment [IMP]
- positive regulation of DNA replication [ISO]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of neutrophil chemotaxis [IMP, ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein localization to plasma membrane [IDA]
- regulation of cell migration [IMP, ISO]
- regulation of respiratory burst [ISO]
- ruffle assembly [IMP]
- ruffle organization [ISO]
- semaphorin-plexin signaling pathway [ISO]
- small GTPase mediated signal transduction [IDA]
- substrate adhesion-dependent cell spreading [IDA, IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [ISO]
- actin filament [ISO]
- cell projection [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of plasma membrane [IDA]
- focal adhesion [ISO]
- lamellipodium [IDA, ISO]
- membrane [IDA, ISO]
- phagocytic cup [IDA]
- ruffle membrane [IDA]
- trans-Golgi network [ISO]
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
The Ubiquitin E3 Ligase TRAF6 Exacerbates Ischemic Stroke by Ubiquitinating and Activating Rac1.
Stroke is one of the leading causes of morbidity and mortality worldwide. Inflammation, oxidative stress, apoptosis, and excitotoxicity contribute to neuronal death during ischemic stroke; however, the mechanisms underlying these complicated pathophysiological processes remain to be fully elucidated. Here, we found that the expression of tumor necrosis factor receptor-associated factor 6 (TRAF6) was markedly increased after cerebral ischemia/reperfusion (I/R) in ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TRAF6 RAC1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
RAC1 TRAF6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
TRAF6 RAC1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
RAC1 TRAF6 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID