BAIT
PTPN2
PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP
protein tyrosine phosphatase, non-receptor type 2
GO Process (34)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- B cell differentiation [ISS]
- T cell differentiation [ISS]
- cytokine-mediated signaling pathway [TAS]
- erythrocyte differentiation [ISS]
- glucose homeostasis [ISS]
- insulin receptor signaling pathway [ISS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of T cell receptor signaling pathway [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of chemotaxis [ISS]
- negative regulation of epidermal growth factor receptor signaling pathway [IMP]
- negative regulation of inflammatory response [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- negative regulation of interferon-gamma-mediated signaling pathway [ISS]
- negative regulation of interleukin-2-mediated signaling pathway [IMP]
- negative regulation of interleukin-4-mediated signaling pathway [IMP]
- negative regulation of interleukin-6-mediated signaling pathway [IMP]
- negative regulation of lipid storage [ISS]
- negative regulation of macrophage colony-stimulating factor signaling pathway [ISS]
- negative regulation of macrophage differentiation [ISS]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [ISS]
- negative regulation of positive thymic T cell selection [ISS]
- negative regulation of prolactin signaling pathway [ISS]
- negative regulation of tumor necrosis factor-mediated signaling pathway [ISS]
- negative regulation of type I interferon-mediated signaling pathway [IMP]
- negative regulation of tyrosine phosphorylation of Stat1 protein [IDA, IMP]
- negative regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- negative regulation of tyrosine phosphorylation of Stat5 protein [ISS]
- negative regulation of tyrosine phosphorylation of Stat6 protein [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- positive regulation of gluconeogenesis [ISS]
- regulation of hepatocyte growth factor receptor signaling pathway [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CORO1C
HCRNN4
coronin, actin binding protein, 1C
GO Process (3)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Coordinated activities of protein kinases and phosphatases ensure phosphorylation homeostasis, which, when perturbed, can instigate diseases, including cancer. Yet, in contrast to kinases, much less is known about protein phosphatase functions and their interactions and complexes. Here, we used quantitative affinity proteomics to assay protein-protein interactions for 54 phosphatases distributed across the three major protein phosphatase families, with additional analysis ... [more]
Cell Syst Apr. 26, 2017; 4(4);430-444.e5 [Pubmed: 28330616]
Throughput
- High Throughput
Curated By
- BioGRID