BAIT
TPTE
CT44, PTEN2
transmembrane phosphatase with tensin homology
GO Process (3)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Homo sapiens
PREY
OPA1
MGM1, NPG, NTG, largeG
optic atrophy 1 (autosomal dominant)
GO Process (11)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- axon transport of mitochondrion [TAS]
- cellular senescence [IDA]
- inner mitochondrial membrane organization [IDA]
- mitochondrial fission [TAS]
- mitochondrial fusion [IDA, IMP, TAS]
- mitochondrial genome maintenance [IMP]
- mitochondrion organization [IMP, NAS]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IGI]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Coordinated activities of protein kinases and phosphatases ensure phosphorylation homeostasis, which, when perturbed, can instigate diseases, including cancer. Yet, in contrast to kinases, much less is known about protein phosphatase functions and their interactions and complexes. Here, we used quantitative affinity proteomics to assay protein-protein interactions for 54 phosphatases distributed across the three major protein phosphatase families, with additional analysis ... [more]
Cell Syst Apr. 26, 2017; 4(4);430-444.e5 [Pubmed: 28330616]
Throughput
- High Throughput
Curated By
- BioGRID