A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Elf1p, a member of the ABC class of ATPases, functions as a mRNA export factor in Schizosacchromyces pombe.

Kozak L, Gopal G, Yoon JH, Sauna ZE, Ambudkar SV, Thakurta AG, Dhar R

Rae1p and Mex67p/Tap are conserved mRNA export factors. We have used synthetic lethal genetic screens in Schizosaccharomyces pombe to identify mutations in genes that are functionally linked to rae1 and mex67 in mRNA export. From these screens, we have isolated mutations in a putative S. pombe homologue of the Candida albicans elf1 gene. The elf1 of S. pombe is not ... [more]

J. Biol. Chem. Sep. 13, 2002; 277(37);33580-9 [Pubmed: 12110682]

Throughput

Low Throughput

Ontology Terms

phenotype: vegetative growth (APO:0000106)

Additional Notes

genetic complex
overexpression of mex67 rescues the growth defects in a rae1/elf1 double mutant

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
MEX67 ELF1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Kozak L (2002)	Low	-	BioGRID	246786
ELF1 MEX67	Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.	Kozak L (2002)	Low	-	BioGRID	676192

Curated By

BioGRID

Interaction Summary

ELF1

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATP binding [IDA]ATPase activity [IDA]

Gene Ontology Cellular Component

MEX67