BAIT
DUSP16
MKP-7, MKP7
dual specificity phosphatase 16
GO Process (5)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
BAG5
BAG-5
BCL2-associated athanogene 5
GO Process (8)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of protein refolding [ISS]
- negative regulation of protein ubiquitination [IMP, ISS]
- negative regulation of ubiquitin-protein transferase activity [ISS]
- neuron death [ISS]
- protein folding [TAS]
- regulation of inclusion body assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Coordinated activities of protein kinases and phosphatases ensure phosphorylation homeostasis, which, when perturbed, can instigate diseases, including cancer. Yet, in contrast to kinases, much less is known about protein phosphatase functions and their interactions and complexes. Here, we used quantitative affinity proteomics to assay protein-protein interactions for 54 phosphatases distributed across the three major protein phosphatase families, with additional analysis ... [more]
Cell Syst Apr. 26, 2017; 4(4);430-444.e5 [Pubmed: 28330616]
Throughput
- High Throughput
Curated By
- BioGRID