Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity.

Molz L, Beach D

We have previously described the isolation of mcs2-75, a mutation obtained as an allele-specific suppressor of a dominant allele of cdc2. mcs2 was cloned and determined to be an essential gene, the product of which shares homology with the cyclin family of proteins. In contrast to the behavior of some, but not all cyclins, the mcs2 protein is constant in ... [more]

EMBO J. Apr. 01, 1993; 12(4);1723-32 [Pubmed: 8467814]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: heat sensitivity (APO:0000147)
  • phenotype: cell cycle progression (APO:0000253)
  • phenotype: nuclear morphology (APO:0000057)
  • phenotype: septum formation (APO:0000221)

Additional Notes

  • csk1 suppresses the temperature sensitivity, cell cycle defect and accumulation of septa and nuclei caused by mutation of mcs2 especially in cdc2/cdc25 mutant backgrounds

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MCS2 CSK1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-5.2168BioGRID
781964

Curated By

  • BioGRID