CALM1
Gene Ontology Biological Process
Gene Ontology Molecular Function- adenylate cyclase binding [ISO]
- calcium ion binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- enzyme regulator activity [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein domain specific binding [ISO]
- type 3 metabotropic glutamate receptor binding [ISO]
- adenylate cyclase binding [ISO]
- calcium ion binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- enzyme regulator activity [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein domain specific binding [ISO]
- type 3 metabotropic glutamate receptor binding [ISO]
Gene Ontology Cellular Component
CAMK2A
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- calcium ion transport [IMP]
- ionotropic glutamate receptor signaling pathway [ISO]
- peptidyl-serine phosphorylation [IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of calcium ion transport [IMP]
- positive regulation of cardiac muscle cell apoptotic process [IMP]
- protein autophosphorylation [IMP, ISO]
- protein phosphorylation [IDA, ISO]
- regulation of mitochondrial membrane permeability involved in apoptotic process [IMP]
- regulation of neuronal synaptic plasticity [IMP]
- regulation of neurotransmitter secretion [IMP]
- response to ischemia [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Calcium-dependent binding of Myc to calmodulin.
The bHLH-LZ (basic region/helix-loop-helix/leucine zipper) oncoprotein Myc and the bHLH-LZ protein Max form a binary transcription factor complex controlling fundamental cellular processes. Deregulated Myc expression leads to neoplastic transformation and is a hallmark of most human cancers. The dynamics of Myc transcription factor activity are post-translationally coordinated by defined protein-protein interactions. Here, we present evidence for a second messenger controlled ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID