BAIT
POP1
SPBC2G2.18, ste16, SPBC1718.01
cullin 1 adaptor protein Pop1
GO Process (5)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
CDC13
SPBC582.03
G2/M B-type cyclin Cdc13
GO Process (7)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- cellular response to nitrogen starvation [IMP]
- negative regulation of G0 to G1 transition [IMP]
- negative regulation of induction of conjugation with cellular fusion [IMP]
- positive regulation of protein localization to nucleus [IMP]
- positive regulation of protein serine/threonine kinase activity [IGI]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18.
In fission yeast, maintenance of genome ploidy is controlled by at least two mechanisms. One operates through the Cdc2/Cdc13 kinase, which also involves the CDK inhibitor Rum1, and the other through the S-phase regulator Cdc18. By screening for sterile mutants that show increased ploidy, we have identified a new gene, pop1+, in mutants that become polyploid. The pop1 mutation shows ... [more]
Genes Dev. Jun. 15, 1997; 11(12);1548-60 [Pubmed: 9203581]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID