A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis.

Uchiyama M, Galli I, Griffiths DJ, Wang TS

A semipermissive growth condition was defined for a Schizosaccharomyces pombe strain carrying a thermosensitive allele of DNA polymerase delta (pol delta ts03). Under this condition, DNA polymerase delta is semidisabled and causes a delay in S-phase progression. Using a genetic strategy, we have isolated a panel of mutants that enter premature mitosis when DNA replication is incomplete but which are ... [more]

Mol. Cell. Biol. Jun. 01, 1997; 17(6);3103-15 [Pubmed: 9154809]

Throughput

Low Throughput

Ontology Terms

phenotype: nuclear morphology (APO:0000057)

Additional Notes

double mutants show a cut nuclear phenotype

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CDC6 RAD26	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Uchiyama M (1997)	Low	-	BioGRID	246836
RAD26 CDC6	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Liu VF (1999)	Low	-	BioGRID	247325

Curated By

BioGRID

Interaction Summary

CDC6

Gene Ontology Biological Process

Gene Ontology Molecular Function

3'-5' exonuclease activity [IC]DNA-directed DNA polymerase activity [ISO]protein binding [IPI]

Gene Ontology Cellular Component

RAD26