A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The Schizosaccharomyces pombe cdt2(+) gene, a target of G1-S phase-specific transcription factor complex DSC1, is required for mitotic and premeiotic DNA replication.

Yoshida SH, Al-Amodi H, Nakamura T, McInerny CJ, Shimoda C

We have defined five sev genes by genetic analysis of Schizosaccharomyces pombe mutants, which are defective in both proliferation and sporulation. sev1(+)/cdt2(+) was transcribed during the G1-S phase of the mitotic cell cycle, as well as during the premeiotic S phase. The mitotic expression of cdt2(+) was regulated by the MCB-DSC1 system. A mutant of a component of DSC1 affected ... [more]

Genetics Jul. 01, 2003; 164(3);881-93 [Pubmed: 12871901]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CDT2 RAD3	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Fleck O (2017)	Low	-	BioGRID	2609803

Curated By

BioGRID

Interaction Summary

CDT2

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]protein binding, bridging [IPI]protein complex binding [IDA]

Gene Ontology Cellular Component

RAD3

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]protein serine/threonine kinase activity [IDA]