BAIT
PTCH1
BCNS, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11, RP11-435O5.3
patched 1
GO Process (21)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- brain development [ISS]
- cellular response to cholesterol [IMP, ISS]
- dorsal/ventral pattern formation [ISS]
- embryonic limb morphogenesis [ISS]
- limb morphogenesis [IMP]
- negative regulation of multicellular organism growth [ISS]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of smoothened signaling pathway [ISS, TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neural plate axis specification [ISS]
- neural tube patterning [IMP]
- organ morphogenesis [ISS]
- pharyngeal system development [IMP]
- positive regulation of cholesterol efflux [IDA]
- protein processing [ISS]
- protein targeting to plasma membrane [IDA]
- regulation of smoothened signaling pathway [ISS]
- renal system development [IEP]
- smoothened signaling pathway [IEP, ISS]
- somite development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAN
ARA24, Gsp1, TC4, OK/SW-cl.81
RAN, member RAS oncogene family
GO Process (15)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- DNA metabolic process [TAS]
- androgen receptor signaling pathway [NAS]
- gene expression [TAS]
- intracellular transport of virus [TAS]
- mitotic nuclear division [TAS]
- mitotic spindle organization [TAS]
- positive regulation of protein binding [IDA]
- positive regulation of transcription, DNA-templated [NAS]
- protein export from nucleus [IDA]
- ribosomal large subunit export from nucleus [IMP]
- ribosomal small subunit export from nucleus [IMP]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.
The Sonic hedgehog (Shh) signaling pathway plays a crucial role in cell proliferation and differentiation via Patched1 (Ptc1), a 12-pass transmembrane receptor protein. The C-terminal cytoplasmic tail of Ptc1 can be cleaved to release the 7th intracellular domain (ICD7), whose function is still unclear. In this study, we found that the ICD7 fragment of Ptc1 associates with polyubiquitinated species. Using ... [more]
Mol. Cell. Biochem. Mar. 01, 2016; 414(1);1-12 [Pubmed: 26885983]
Throughput
- High Throughput
Curated By
- BioGRID