BAIT
PTCH1
BCNS, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11, RP11-435O5.3
patched 1
GO Process (21)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- brain development [ISS]
- cellular response to cholesterol [IMP, ISS]
- dorsal/ventral pattern formation [ISS]
- embryonic limb morphogenesis [ISS]
- limb morphogenesis [IMP]
- negative regulation of multicellular organism growth [ISS]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of smoothened signaling pathway [ISS, TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neural plate axis specification [ISS]
- neural tube patterning [IMP]
- organ morphogenesis [ISS]
- pharyngeal system development [IMP]
- positive regulation of cholesterol efflux [IDA]
- protein processing [ISS]
- protein targeting to plasma membrane [IDA]
- regulation of smoothened signaling pathway [ISS]
- renal system development [IEP]
- smoothened signaling pathway [IEP, ISS]
- somite development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TYK2
IMD35, JTK1
tyrosine kinase 2
GO Process (10)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cell differentiation [IBA]
- cell migration [IBA]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- protein phosphorylation [TAS]
- regulation of cell proliferation [IBA]
- regulation of type I interferon-mediated signaling pathway [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.
The Sonic hedgehog (Shh) signaling pathway plays a crucial role in cell proliferation and differentiation via Patched1 (Ptc1), a 12-pass transmembrane receptor protein. The C-terminal cytoplasmic tail of Ptc1 can be cleaved to release the 7th intracellular domain (ICD7), whose function is still unclear. In this study, we found that the ICD7 fragment of Ptc1 associates with polyubiquitinated species. Using ... [more]
Mol. Cell. Biochem. Mar. 01, 2016; 414(1);1-12 [Pubmed: 26885983]
Throughput
- High Throughput
Curated By
- BioGRID