TNFRSF1A
Gene Ontology Biological Process
- cell surface receptor signaling pathway [ISO, ISS]
- cellular response to estradiol stimulus [IEP]
- cellular response to mechanical stimulus [ISO]
- cytokine-mediated signaling pathway [ISO, ISS]
- defense response [ISO, ISS]
- defense response to bacterium [ISO]
- inflammatory response [IEP, ISO, ISS]
- intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of gene expression [IDA]
- negative regulation of inflammatory response [ISO]
- negative regulation of interleukin-6 production [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of angiogenesis [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of inflammatory response [ISO, ISS]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of protein import into nucleus, translocation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- positive regulation of tumor necrosis factor production [IMP]
- positive regulation of tyrosine phosphorylation of Stat1 protein [ISO]
- programmed cell death [ISO]
- protein heterooligomerization [IPI]
- regulation of apoptotic process [IMP]
- response to alkaloid [IEP]
- response to amino acid [IEP]
- response to ethanol [IEP]
- response to hypoxia [IEP]
- response to lipopolysaccharide [IEP]
- response to wounding [IEP]
- tetrapyrrole metabolic process [IEP]
- tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TRADD
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death.
The consequences of activation of tumour necrosis factor receptor 1 (TNFR1) during neuronal injury remain controversial. The apoptosis signal-regulating kinase 1 (ASK1), a mitogen-activated protein kinase kinase kinase, can mediate cell death downstream of TNFR1. Presently, we examined the formation of the TNFR1 signalling cascade and response of ASK1 during seizure-induced neuronal death. Brief (40 min) seizures were induced in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID