BAIT

FGFR1

BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1

fibroblast growth factor receptor 1

Glioblastoma Project

Synthetic Protein Interaction Project

GO Process (25)

GO Function (7)

GO Component (5)

Gene Ontology Biological Process

Fc-epsilon receptor signaling pathway [TAS]

MAPK cascade [TAS]

axon guidance [TAS]

cell migration [TAS]

chordate embryonic development [TAS]

epidermal growth factor receptor signaling pathway [TAS]

fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]

innate immune response [TAS]

insulin receptor signaling pathway [TAS]

neuron migration [TAS]

neurotrophin TRK receptor signaling pathway [TAS]

peptidyl-tyrosine phosphorylation [IDA]

phosphatidylinositol-mediated signaling [TAS]

positive regulation of MAP kinase activity [IDA]

positive regulation of MAPK cascade [IMP]

positive regulation of cell proliferation [IDA, IGI, IMP]

positive regulation of neuron differentiation [IMP]

positive regulation of phosphatidylinositol 3-kinase signaling [TAS]

positive regulation of phospholipase C activity [IDA]

positive regulation of phospholipase activity [TAS]

protein autophosphorylation [IDA]

protein phosphorylation [NAS]

regulation of cell differentiation [TAS]

skeletal system development [TAS]

skeletal system morphogenesis [TAS]

Gene Ontology Molecular Function

fibroblast growth factor binding [IDA]
fibroblast growth factor-activated receptor activity [IDA, TAS]
heparin binding [IDA]
identical protein binding [IPI]
protein binding [IPI]
protein homodimerization activity [IPI]
protein tyrosine kinase activity [IDA]

Gene Ontology Cellular Component

extracellular region [NAS]

integral component of membrane [NAS]

integral component of plasma membrane [TAS]

plasma membrane [IDA, TAS]

receptor complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

COPA

HEP-COP

coatomer protein complex, subunit alpha

GO Process (4)

GO Function (0)

GO Component (6)

Gene Ontology Biological Process

COPI coating of Golgi vesicle [TAS]

membrane organization [TAS]

pancreatic juice secretion [IDA]

retrograde vesicle-mediated transport, Golgi to ER [TAS]

Gene Ontology Cellular Component

COPI vesicle coat [IDA, ISS]

cytoplasm [IDA]

extracellular space [IDA]

extracellular vesicular exosome [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Protein partners in the life history of activated fibroblast growth factor receptors.

Vecchione A, Cooper HJ, Trim KJ, Akbarzadeh S, Heath JK, Wheldon LM

Fibroblast growth factor receptors (FGFRs) are a family of four transmembrane (TM) receptor tyrosine kinases (RTKs) which bind to a large family of fibroblast growth factor (FGF) ligands with varying affinity and specificity. FGFR signaling regulates many physiological and pathological processes in development and tissue homeostasis. Understanding FGFR signaling processes requires the identification of partner proteins which regulate receptor function ... [more]

Proteomics Dec. 01, 2007; 7(24);4565-78 [Pubmed: 18022941]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
FGFR1 COPA	Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.	Salokas K (2022)	High	0	BioGRID	3507646

Curated By

BioGRID