BAIT
IL17RD
HH18, IL-17RD, IL17RLM, SEF, UNQ6115/PRO20026
interleukin 17 receptor D
GO Process (1)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FGFR2
AU043015, AW556123, Bek, Fgfr-2, Fgfr-7, Fgfr7, KGFR, KGFRTr, svs
fibroblast growth factor receptor 2
GO Process (102)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- angiogenesis [IGI]
- axonogenesis [IMP]
- bone development [IMP]
- bone mineralization [IMP]
- bone morphogenesis [IMP]
- branch elongation involved in salivary gland morphogenesis [IGI, IMP]
- branching involved in labyrinthine layer morphogenesis [IMP]
- branching involved in prostate gland morphogenesis [IMP]
- branching involved in salivary gland morphogenesis [IMP]
- branching morphogenesis of a nerve [IMP]
- bud elongation involved in lung branching [IMP]
- cell fate commitment [IDA]
- cell-cell signaling [IMP]
- coronal suture morphogenesis [IMP]
- digestive tract development [IMP]
- embryonic cranial skeleton morphogenesis [ISO]
- embryonic digestive tract morphogenesis [IMP]
- embryonic organ development [IMP]
- embryonic organ morphogenesis [IMP]
- embryonic pattern specification [IMP]
- endodermal digestive tract morphogenesis [IMP]
- epidermis morphogenesis [IMP]
- epithelial cell differentiation [IMP]
- epithelial cell proliferation [IMP]
- epithelial cell proliferation involved in salivary gland morphogenesis [IGI, IMP]
- epithelial to mesenchymal transition [ISO]
- epithelial tube branching involved in lung morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [IGI, IMP, ISO]
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis [IMP]
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification [IMP]
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow [IMP]
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [IMP]
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow [IMP]
- gland morphogenesis [IMP]
- hair follicle morphogenesis [IMP]
- in utero embryonic development [IGI, IMP]
- inner ear morphogenesis [IMP]
- lacrimal gland development [IMP]
- lateral sprouting from an epithelium [IMP]
- lens fiber cell development [IGI, IMP]
- limb bud formation [IMP]
- lung alveolus development [IGI, IMP]
- lung development [IGI, IMP]
- lung lobe morphogenesis [IMP]
- lung-associated mesenchyme development [IGI, IMP]
- mammary gland bud formation [IMP]
- membranous septum morphogenesis [IMP]
- mesenchymal cell differentiation [IGI]
- mesenchymal cell differentiation involved in lung development [IGI]
- mesenchymal cell proliferation involved in lung development [IMP]
- midbrain development [IGI]
- morphogenesis of embryonic epithelium [IMP]
- multicellular organism growth [IMP]
- negative regulation of cell proliferation [IGI]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of mitosis [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neuromuscular junction development [IMP]
- odontogenesis [IMP]
- orbitofrontal cortex development [IMP]
- organ growth [IMP]
- organ morphogenesis [IMP]
- otic vesicle formation [IMP]
- outflow tract septum morphogenesis [IMP]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [IGI]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Wnt signaling pathway [IMP]
- positive regulation of canonical Wnt signaling pathway [IGI, IMP]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of cell cycle [IMP]
- positive regulation of cell division [IMP]
- positive regulation of cell proliferation [IGI, IMP, ISO]
- positive regulation of epithelial cell proliferation [IGI]
- positive regulation of epithelial cell proliferation involved in lung morphogenesis [IMP]
- positive regulation of mesenchymal cell proliferation [IGI]
- positive regulation of phospholipase activity [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- post-embryonic development [IMP]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [IMP]
- prostate epithelial cord elongation [IMP]
- prostate gland morphogenesis [IMP]
- protein autophosphorylation [ISO]
- pyramidal neuron development [IMP]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of branching involved in prostate gland morphogenesis [IMP]
- regulation of cell fate commitment [IMP]
- regulation of cell proliferation [IMP]
- regulation of epithelial cell proliferation [IMP]
- regulation of fibroblast growth factor receptor signaling pathway [IMP]
- regulation of morphogenesis of a branching structure [IMP]
- regulation of multicellular organism growth [IMP]
- regulation of smooth muscle cell differentiation [IMP]
- regulation of smoothened signaling pathway [IMP]
- reproductive structure development [IMP]
- squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [IMP]
- synaptic vesicle transport [IMP]
- ureteric bud development [IGI]
- vasculogenesis involved in coronary vascular morphogenesis [TAS]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- ventricular zone neuroblast division [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling.
Growth factor signaling by receptor tyrosine kinases regulates several cell fates, such as proliferation and differentiation. Sef was genetically identified as a negative regulator of fibroblast growth factor (FGF) signaling. Using bioinformatic methods and rapid amplification of cDNA ends-PCR, we isolated both the mouse and the human Sef genes, which encoded the Sef protein and Sef-S isoform that was generated ... [more]
J. Biol. Chem. Dec. 12, 2003; 278(50);50273-82 [Pubmed: 12958313]
Throughput
- Low Throughput
Curated By
- BioGRID