ACVR2A
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, TAS]
- activin receptor signaling pathway [IDA]
- cellular response to BMP stimulus [IMP]
- positive regulation of activin receptor signaling pathway [IDA]
- positive regulation of bone mineralization [IMP]
- positive regulation of erythrocyte differentiation [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of protein phosphorylation [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TDGF1
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- anterior/posterior axis specification, embryo [ISS]
- cell differentiation [TAS]
- cell migration involved in sprouting angiogenesis [IMP]
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to hepatocyte growth factor stimulus [IDA]
- cellular response to interferon-gamma [IDA]
- cellular response to interleukin-6 [IDA]
- cellular response to tumor necrosis factor [IDA]
- embryo development [TAS]
- epidermal growth factor receptor signaling pathway [IDA]
- heart development [IDA]
- mammary gland development [TAS]
- morphogenesis of a branching structure [TAS]
- negative regulation of apoptotic process [IDA]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA, TAS]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- regulation of signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic.
Transforming growth factor β (TGF-β) pathways are key determinants of cell fate in animals. Their basic mechanism of action is simple. However, to produce cell-specific responses, TGF-β pathways are heavily regulated by secondary factors, such as membrane-associated EGF-CFC family proteins. Cellular activities of EGF-CFC proteins have been described, but their molecular functions, including how the mammalian homologs Cripto-1 and Cryptic ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID