ACVR1B
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- activin receptor signaling pathway [IDA, IMP]
- extrinsic apoptotic signaling pathway [IMP]
- negative regulation of cell growth [IDA]
- nodal signaling pathway [IGI]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of activin receptor signaling pathway [IDA]
- positive regulation of erythrocyte differentiation [IDA]
- positive regulation of trophoblast cell migration [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [IDA]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- activin-activated receptor activity [IDA]
- growth factor binding [IPI]
- inhibin binding [IPI]
- protein binding [IPI]
- protein serine/threonine kinase activity [EXP, IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ubiquitin protein ligase binding [NAS]
- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- activin-activated receptor activity [IDA]
- growth factor binding [IPI]
- inhibin binding [IPI]
- protein binding [IPI]
- protein serine/threonine kinase activity [EXP, IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ubiquitin protein ligase binding [NAS]
Gene Ontology Cellular Component
NODAL
Gene Ontology Biological Process
- SMAD protein signal transduction [IBA]
- endodermal cell differentiation [IMP]
- mesendoderm development [IMP]
- negative regulation of androgen receptor signaling pathway [IDA]
- negative regulation of chorionic trophoblast cell proliferation [IDA]
- negative regulation of trophoblast cell migration [IDA]
- placenta development [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of SMAD protein import into nucleus [IMP]
- positive regulation of activin receptor signaling pathway [IGI]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell-cell adhesion [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [ISS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation vascular endothelial growth factor production [IMP]
- regulation of stem cell maintenance [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic.
Transforming growth factor β (TGF-β) pathways are key determinants of cell fate in animals. Their basic mechanism of action is simple. However, to produce cell-specific responses, TGF-β pathways are heavily regulated by secondary factors, such as membrane-associated EGF-CFC family proteins. Cellular activities of EGF-CFC proteins have been described, but their molecular functions, including how the mammalian homologs Cripto-1 and Cryptic ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID