PPIA
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DDX58
Gene Ontology Biological Process
- RIG-I signaling pathway [ISO]
- detection of virus [ISO]
- innate immune response [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of interferon-alpha production [ISO]
- positive regulation of interferon-beta production [IMP, ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of cell migration [ISO]
- response to exogenous dsRNA [IMP]
- response to virus [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses.
RIG-I is a key cytosolic pattern recognition receptor that interacts with MAVS to induce type I interferons (IFNs) against RNA virus infection. In this study, we found that cyclophilin A (CypA), a peptidyl-prolyl cis/trans isomerase, functioned as a critical positive regulator of RIG-I-mediated antiviral immune responses. Deficiency of CypA impaired RIG-I-mediated type I IFN production and promoted viral replication in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID