BAIT
RNF8
ring finger protein 8, E3 ubiquitin protein ligase
GO Process (16)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [ISO, ISS]
- double-strand break repair [ISO, ISS]
- double-strand break repair via nonhomologous end joining [ISO, ISS]
- histone H2A K63-linked ubiquitination [ISO, ISS]
- histone H2A ubiquitination [ISO, ISS]
- histone H2B ubiquitination [ISO, ISS]
- histone exchange [ISO, ISS]
- isotype switching [ISO, ISS]
- negative regulation of transcription elongation from RNA polymerase II promoter [ISO, ISS]
- positive regulation of DNA repair [ISO, ISS]
- protein K48-linked ubiquitination [ISO, ISS]
- protein K63-linked ubiquitination [ISO, ISS]
- protein autoubiquitination [ISO]
- response to ionizing radiation [ISO, ISS]
- spermatid development [ISO, ISS]
- ubiquitin-dependent protein catabolic process [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GLE1
4933405K21Rik, AA553313, Gle1l, RP23-443G7.5
GLE1 RNA export mediator (yeast)
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain.
Although ubiquitin ligases have been implicated in autism, their roles and mechanisms in brain development remain incompletely understood. Here, we report that in vivo knockdown or conditional knockout of the autism-linked ubiquitin ligase RNF8 or associated ubiquitin-conjugating enzyme UBC13 in rodent cerebellar granule neurons robustly increases the number of parallel fiber presynaptic boutons and functional parallel fiber/Purkinje cell synapses. In ... [more]
Nat Commun Dec. 02, 2016; 8(1);1271 [Pubmed: 29097665]
Throughput
- Low Throughput
Curated By
- BioGRID